Definition
Brand name for esketamine intranasal spray, manufactured by Janssen. FDA-approved in 2019 for treatment-resistant depression; administered only in certified clinics under a Risk Evaluation and Mitigation Strategy (REMS).
Related Terms
Esketamine
The (S)-enantiomer of ketamine, FDA-approved as the nasal spray Spravato for treatment-resistant depression and depressive symptoms in adults with major depressive disorder with acute suicidal ideation or behavior.
Ketamine
A dissociative anesthetic developed in the 1960s, now used at sub-anesthetic doses for treatment-resistant depression and other mental health conditions.
Treatment-Resistant Depression (TRD)
A subtype of major depressive disorder defined by inadequate response to at least two adequate trials of antidepressant medications from different classes.
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